Specifically....

Could not load type 'System.Runtime.CompilerServices.ExtensionAttribute' from assembly 'mscorlib, Version=4.0.0.0, Culture=neutral, PublicKeyToken=b77a5c561934e089'.
at System.ModuleHandle.ResolveType(RuntimeModule module, Int32 typeToken, IntPtr* typeInstArgs, Int32 typeInstCount, IntPtr* methodInstArgs, Int32 methodInstCount, ObjectHandleOnStack type) at System.ModuleHandle.ResolveTypeHandleInternal(RuntimeModule module, Int32 typeToken, RuntimeTypeHandle[] typeInstantiationContext, RuntimeTypeHandle[] methodInstantiationContext) at System.Reflection.RuntimeModule.ResolveType(Int32 metadataToken, Type[] genericTypeArguments, Type[] genericMethodArguments) at System.Reflection.CustomAttribute.FilterCustomAttributeRecord(CustomAttributeRecord caRecord, MetadataImport scope, Assembly& lastAptcaOkAssembly, RuntimeModule decoratedModule, MetadataToken decoratedToken, RuntimeType attributeFilterType, Boolean mustBeInheritable, Object[] attributes, IList derivedAttributes, RuntimeType& attributeType, IRuntimeMethodInfo& ctor, Boolean& ctorHasParameters, Boolean& isVarArg) at System.Reflection.CustomAttribute.GetCustomAttributes(RuntimeModule decoratedModule, Int32 decoratedMetadataToken, Int32 pcaCount, RuntimeType attributeFilterType, Boolean mustBeInheritable, IList derivedAttributes, Boolean isDecoratedTargetSecurityTransparent) at System.Reflection.CustomAttribute.GetCustomAttributes(RuntimeAssembly assembly, RuntimeType caType) at System.Reflection.RuntimeAssembly.GetCustomAttributes(Type attributeType, Boolean inherit) at System.Runtime.Serialization.DataContract.IsAssemblyFriendOfSerialization(Assembly assembly) at System.Runtime.Serialization.DataContract.IsTypeVisibleInSerializationModule(Type type) at System.Runtime.Serialization.DataContract.IsMemberVisibleInSerializationModule(MemberInfo member) at System.Runtime.Serialization.DataContract.FieldRequiresMemberAccess(FieldInfo field) at System.Runtime.Serialization.DataMember.RequiresMemberAccessForGet() at System.Runtime.Serialization.ClassDataContract.RequiresMemberAccessForWrite(SecurityException securityException) at System.Runtime.Serialization.Json.JsonFormatWriterGenerator.CriticalHelper.GenerateClassWriter(ClassDataContract classContract) at System.Runtime.Serialization.Json.JsonClassDataContract.get_JsonFormatWriterDelegate() at System.Runtime.Serialization.Json.JsonClassDataContract.WriteJsonValueCore(XmlWriterDelegator jsonWriter, Object obj, XmlObjectSerializerWriteContextComplexJson context, RuntimeTypeHandle declaredTypeHandle) at System.Runtime.Serialization.Json.XmlObjectSerializerWriteContextComplexJson.WriteDataContractValue(DataContract dataContract, XmlWriterDelegator xmlWriter, Object obj, RuntimeTypeHandle declaredTypeHandle) at System.Runtime.Serialization.XmlObjectSerializerWriteContext.SerializeWithoutXsiType(DataContract dataContract, XmlWriterDelegator xmlWriter, Object obj, RuntimeTypeHandle declaredTypeHandle) at System.Runtime.Serialization.Json.DataContractJsonSerializer.InternalWriteObjectContent(XmlWriterDelegator writer, Object graph) at System.Runtime.Serialization.Json.DataContractJsonSerializer.InternalWriteObject(XmlWriterDelegator writer, Object graph) at System.Runtime.Serialization.XmlObjectSerializer.InternalWriteObject(XmlWriterDelegator writer, Object graph, DataContractResolver dataContractResolver) at System.Runtime.Serialization.XmlObjectSerializer.WriteObjectHandleExceptions(XmlWriterDelegator writer, Object graph, DataContractResolver dataContractResolver) at System.Runtime.Serialization.Json.DataContractJsonSerializer.WriteObject(XmlDictionaryWriter writer, Object graph) at System.Runtime.Serialization.Json.DataContractJsonSerializer.WriteObject(Stream stream, Object graph) at MonoSoftware.Core.JsonSerializer.GetBytes(Object content, Type type) at MonoSoftware.MonoX.ModuleGallery.SilverlightUploadModule.get_InitParameters() at ASP.monox_modulegallery_silverlightuploadmodule_ascx.__RenderpnlUpload(HtmlTextWriter __w, Control parameterContainer) in c:\Webs\MonoX\mentor1\MonoX\ModuleGallery\SilverlightUploadModule.ascx:line 21 at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.WebControls.WebControl.RenderContents(HtmlTextWriter writer) at System.Web.UI.WebControls.WebControl.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at MonoSoftware.MonoX.BasePart.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.WebControls.WebControl.RenderContents(HtmlTextWriter writer) at System.Web.UI.WebControls.WebControl.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.UpdatePanel.RenderChildren(HtmlTextWriter writer) at System.Web.UI.UpdatePanel.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.WebControls.WebControl.RenderContents(HtmlTextWriter writer) at System.Web.UI.WebControls.WebControl.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at MonoSoftware.MonoX.BasePart.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.WebControls.WebControl.RenderContents(HtmlTextWriter writer) at System.Web.UI.WebControls.WebParts.GenericWebPart.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.WebControls.WebParts.WebPartChrome.RenderPartContents(HtmlTextWriter writer, WebPart webPart) at MonoSoftware.MonoX.TemplatedWebPartChrome.RenderPartContents(WebPart webPart) at MonoSoftware.MonoX.TemplatedWebPartChrome.GenerateContentFromTemplate(StringBuilder sb, WebPart webPart) at MonoSoftware.MonoX.TablelessWebPartChrome.RenderWebPart(HtmlTextWriter writer, WebPart webPart) at MonoSoftware.MonoX.PortalWebPartZoneTableless.RenderBody(HtmlTextWriter writer) at MonoSoftware.MonoX.PortalWebPartZoneTableless.RenderContents(HtmlTextWriter writer) at MonoSoftware.MonoX.PortalWebPartZoneTableless.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at ASP.monox_masterpages_default_master.__Render__control2(HtmlTextWriter __w, Control parameterContainer) in c:\Webs\MonoX\mentor1\MonoX\MasterPages\Default.master:line 23 at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.UpdatePanel.RenderChildren(HtmlTextWriter writer) at System.Web.UI.UpdatePanel.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.HtmlControls.HtmlForm.RenderChildren(HtmlTextWriter writer) at System.Web.UI.HtmlControls.HtmlContainerControl.Render(HtmlTextWriter writer) at System.Web.UI.HtmlControls.HtmlForm.Render(HtmlTextWriter output) at MonoSoftware.MonoX.UrlRewriter.FormRewriterControlAdapter.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.HtmlControls.HtmlForm.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at System.Web.UI.Control.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Control.RenderChildrenInternal(HtmlTextWriter writer, ICollection children) at System.Web.UI.Control.RenderChildren(HtmlTextWriter writer) at MonoSoftware.MonoX.BasePage.#lj() at MonoSoftware.MonoX.BasePage.Render(HtmlTextWriter writer) at System.Web.UI.Control.RenderControlInternal(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer, ControlAdapter adapter) at System.Web.UI.Control.RenderControl(HtmlTextWriter writer) at System.Web.UI.Page.ProcessRequestMain(Boolean includeStagesBeforeAsyncPoint, Boolean includeStagesAfterAsyncPoint)

Hi,

"Is this a result of missing files or of a .NET 4.5 assembly giving us trouble? I saw mention of a different Monox.Framework binary on another support request.Can you help me resolve this issue please?"
Yes, this is an issue with missing .NET 4.5 on your machine, as we are moving towards the .NET 4.5 with 4.9 and 5.x versions. You should install .NET 4.5 on the machine and everything should work properly. This is a "breaking" change on .NET 4.0-4.5 

Let us know if you need anything else, and if installing .NET 4.5 on your machine is not an option we can provide you with dlls for .NET 4.0 version around Tuesday next week.

Regards