All standard ASP.NET practices for increasing scalability work with MonoX (http://msdn.microsoft.com/en-us/magazine/cc500561.aspx , http://www.codeproject.com/Articles/23306/10-ASP-NET-Performance-and-Scalability-Secrets , ...) On MonoX side, you will gain a lot with clever use of caching techniques. Almost all of the parts included with MonoX are "cache-aware", meaning that you just need to switch the configuration setting to turn the partial caching on. The greatest increase in performance can be obtained by using page-level caching (more info can be found in the user manual). Note that caching is more of an art than science, and it takes careful planning to take the complete advantage of it - blindly turning on caching everywhere is never a good decision.