Can you please reassure that you downloaded latest build, that you unblocked the zip file prior extraction (please remove all files before you try to extract the unblocked zip), setup MonoX and check if your application pool is running under the account e.g. Network Service.
I see that you mentioned that you have Full Trust on app pool but I'm not sure if your account has adequate permissions, also this exception tends to be misleading and in most cases ends up as a blocking zip issue.
Let me know if that is the case.
Regards
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