Hi Hewie,
We have sites with up to 500-600 k of users that are running on top of MonoX. There are some additional numbers in the tutorial, based on the load testing of a standard site (social networking features included) performed on a single server. SPs can make the difference in specific scenarios (but are much more difficult to work with and maintain), and we are using them when we need to gain evey bit of performance. Nothing prevents you from using SPs with LLBLGen in your custom projects. Additionally, caching is the feature that can bring dramatic improvements, and we use it a lot.
As for the cloud-based infrastructures that are supported, we have MonoX running under Amazon EC2, with support for Azure and AppHarbor in the works.
There are no simple rules here. A lot of time can be spent on optimization (SQL server, indexing, fragmentation, design that supports page-level caching, etc.) - we feel that the base framework gives you a solid foundation you can use to build a scalable solution. BTW, we also like the NoSQL approach - there are some plans to support it in the future.
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